Journal of Medicinal and Pharmaceutical Chemistry Research

Plasma levels of miR-29a and miR-146a in relation to carotid intima media thickness measurement for detection of carotid atherosclerosis

Heba Fawzy; Nermin Saad; Khaled Ahmed Elbanna; Huda E. M. Said; Rania Yehia Helal; Hend Sameh

Articles in Press, Accepted Manuscript, Available Online from 30 April 2024

https://doi.org/10.48309/jmpcr.2024.445435.1130

Abstract

Atherosclerotic vascular disorders and its sequalae, involving myocardial infarction and stroke, are major reasons of human diseases and death globally. Moreover, carotid intima media ... Read More

Circulating microRNA-16 and microRNA- 106a as novel biomarkers in inflammatory bowel disease

Heba Fawzy; Sherif Swilam; Huda E.M. Said; Abd El-Fattah Mohammed; Mahmoud Amer; Doaa M. Hendawy

Articles in Press, Accepted Manuscript, Available Online from 06 May 2024

https://doi.org/10.48309/jmpcr.2024.449561.1150

Abstract

Inflammatory Bowel Disease (IBD) includes Crohn’s Disease (CD), and Ulcerative Colitis (UC), the two main types of IBD. The IBD incidence is rising globally and among the young ... Read More Inflammatory Bowel Disease (IBD) includes Crohn’s Disease (CD), and Ulcerative Colitis (UC), the two main types of IBD. The IBD incidence is rising globally and among the young age. Endoscopy has a principal role in rating IBD mucosal lesions. Though, it is expensive and invasive. MicroRNAs could be included in regulation of particular genes and included in inflammation. Disorders in microRNAs levels might cause disease development. The objective of our study is to investigate the role of microRNA-16 and microRNA- 106a levels as indicators for diagnosis and assessing the IBD activity. The values of miR 16 and miR 106a were measured in plasma from 20 healthy volunteers (group I) and 40 UC patients (group II) and 40 CD patients (group III) by quantitative real time-PCR (qRT-PCR). Endoscopic severity index was calculated based on laboratory and endoscopic findings. Significant upregulation of miR 16 and miR 106a levels in group II and group III than group I. A positive correlation was demonstrated between both miR 16 and miR 106a with endoscopic severity index. ROC curves of miR 16 for detecting UC showed sensitivity and specificity of 92.5 % and 90 % particularly. ROC curves of miR 106a for differentiating active from inactive CD showed sensitivity and specificity of 90 % and 75 % particularrly. both miR 16 and miR 106a could act as promising biomarkers of IBD diagnosis and assessing its activity aiding in its proper management.Methods: The values of miR 16 and miR 106a were measured in plasma from 20 healthy volunteers (group I) and 40 UC patients (group II) and 40 CD patients. (group III) by quantitative real time –PCR ( qRT-PCR) .Endoscopic severity index was calculated based on laboratory and endoscopic findings .Results: Significant upregulation of miR 16 and miR 106a levels in group II and group III than group I. A positive correlation was demonstrated between both miR 16 and miR 106a with endoscopic severity index. ROC curves of miR 16 for detection of UC showed sensitivity and specificity of 92.5 % and 90 % particularly. ROC curves of miR 106a for differentiating active from inactive CD showed sensitivity and specificity of 90 % and 75 % particularly.Conclusion: both miR 16 and miR 106a could act as promising biomarkers of IBD diagnosis and assessing its activity aiding in its proper management .

The value of plasma mir 126 and miR 423-3p levels in prediction of subclinical atherosclerotic coronary artery disease

Heba Fawzy; Doaa M. Hendawy; Mohammed S. Ghareeb; Mahmoud Amer; Hend Sameh; Hala Mosaad

Volume 6, Issue 5 , May 2024, , Pages 609-622

https://doi.org/10.48309/jmpcr.2024.428610.1050

Abstract

Coronary artery disease (CAD) refers to the progressive development of atherosclerosis, which is a global significant mortality cause, initial diagnosis of CAD is a challenge. Consequently, ... Read More

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Author = Fawzy, Heba

Plasma levels of miR-29a and miR-146a in relation to carotid intima media thickness measurement for detection of carotid atherosclerosis

Abstract

Circulating microRNA-16 and microRNA- 106a as novel biomarkers in inflammatory bowel disease

Abstract

The value of plasma mir 126 and miR 423-3p levels in prediction of subclinical atherosclerotic coronary artery disease

Abstract